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HMC Steering Committee Meeting=
Alexandria, VA
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8AvH8AzX8A3n8A738A8H8RAX8REn8RI3cQaHgBRX8RVn8RZ38ReH8RiX8Rmn8Rq38RvH8RzX8R3n 8R738R8H8iAX8iEn8iI38iNH8iRX8iVn8iZ38ieH8iiX8imn8iq38ivH8izX8i3n8i738i9v8QgQ 8zEn83IyN/MzR/M0V/M1Z/M2d/M3h/M4l/M5p/M6t/M7x/M81/M95/M+9/M/B3QzB4BBJ/RCN/RD R/REV/RFZ/RGd/RHh/RIl/RJp/RKt/RLx/RM1/RN5/RO9/RPB/VQF/VRJ/VSN/VTR/VUV/VVZ/VW d3VRDwgAOw== ------=_NextPart_01C6F84C.1D52B3C0 Content-Location: file:///C:/6E4BB24E/SteveBellPresentation_files/slide0032.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Missing Data
Outline
<= span class=3DBB style=3D'position:absolute;left:-4.11%'>•Types of = missing data
<= span style=3D'visibility:hidden'>•
•Approache= s to handling missing data
<= span style=3D'visibility:hidden'>•
<= span class=3DBB style=3D'position:absolute;left:-4.11%'>•Conclusio= ns
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Types of Missing Data
&#= 8226;Attrition
• <= /div>
–= Once gone, never to return
–
–= Monotone
R= 11;
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Reasons for Attrition
&#= 8226;Life happens
= 211;
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Recruiter/Inte= rventionist/Coordinator:
&= #13;
“Hello Mrs. Participant.  I’m calling to schedule = ;
your 10 year follow-up visit in the BestTrialEver=
Study.  As you may recall, this is a visit in which
you come to the office for about 4 hours to =
answer 3 hours of fun, but nosy, questions and &#= 13;
give a gallon of blood.
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Recruiter/Inte= rventionist/Coordinator:
&= #13;
“Well congratulations on the recent birth o= f your
sextuplets.  That must be quite a handful having 6
infants scurrying around and keeping totally = ;
different awake/sleep cycles.”
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Recruiter/Inte= rventionist/Coordinator:
&= #13;
“What do you mean you can’t make it in for the rest of your visits?   Just drag the little bugger= s in = so we can get our follow-up information.  I’m sure they’ll be just fine in the waiting room by= = themselves.”
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Reasons for Attrition
•Life happens
•<= /span>
•Death happens
•
•
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Other Reasons for Attrition
&#= 8226;Loss to follow-up
• <= /div>
&#= 8226;Lose interest in research
• <= /div>
&#= 8226;Treatment has adverse effect(s)
&= #8211; Participant decision
&= #8211; Interventionist decision
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Types of Missing Data
<= span class=3DBB style=3D'position:absolute;left:-4.43%'>•Attrition=
<= span style=3D'visibility:hidden'>•
<= span class=3DBB style=3D'position:absolute;left:-4.43%'>•Missed vi= sit
<= span style=3D'visibility:hidden'>•
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Recruiter/Inte= rventionist/Coordinator:
&= #13;
“Why can’t you put off your 50th wedding anniversary around the world cruise to complete <= /span>your 20th consecutive followup?  Don’t you remember the commitment you made at the beginning of this study?”
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Types of Missing Data
•Attrition
•<= /span>
•Missed visit
<= span style=3D'mso-special-format:bullet;position:absolute;left:-4.43%'>•<= /span>
•Missed data collection instrument =
<= span style=3D'mso-special-format:bullet;position:absolute;left:-4.43%'>•<= /span>
•Missed item
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Reasons for Missing Data
<= span class=3DBB style=3D'position:absolute;left:-4.19%'>•Don’= ;t know the answer
<= span style=3D'visibility:hidden'>•
•None of t= he choices are appropriate
<= span style=3D'visibility:hidden'>•
<= span class=3DBB style=3D'position:absolute;left:-4.19%'>•Did not s= ee the question
<= span style=3D'visibility:hidden'>•
<= span class=3DBB style=3D'position:absolute;left:-4.19%'>•Refuse to= respond
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Types of Missing Data
<= span class=3DBB style=3D'position:absolute;left:-4.43%'>•Missing outcome
<= span style=3D'visibility:hidden'>•
<= span class=3DBB style=3D'position:absolute;left:-4.43%'>•Missing c= ovariate
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Types of Missing Data
R= 26;Missing value unrelated to anything being measured
–
–Missing completely at random (MCAR)
–
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Types of Missing Data
R= 26;Missing value may be related to other variables, but not to the = value that is missing
–
–Missing at random (MAR)
–
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Types of Missing Data
&#= 8226;Related to outcome
• <= /div>
–Missing Not at Random (MNAR)
– = ;
–Nonignorable missing
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